SEC Filings

10-K
ARRAY BIOPHARMA INC filed this Form 10-K on 08/11/2017
Entire Document
 

ITEM 1.     BUSINESS

Our Business

Array BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Nine registration studies are currently advancing related to eight Array-owned or partnered drugs: binimetinib (MEK162), encorafenib (LGX818), selumetinib (partnered with AstraZeneca), danoprevir (partnered with Roche), ipatasertib (partnered with Genentech), larotrectinib (partnered with Loxo Oncology), tucatinib (partnered with Cascadian Therapeutics) and varlitinib (partnered with Aslan Pharmaceuticals).
Our most significant clinical stage drugs include:
 
Drug Candidate
 
Target/Indication
 
Partner
 
Clinical Status
 
Binimetinib
 
MEK inhibitor for cancer
 
Pierre Fabre Medicament SAS and Ono Pharmaceutical Co., Ltd.
 
Phase 3 / NDA
 
Encorafenib
 
BRAF inhibitor for cancer
 
Pierre Fabre Medicament SAS and Ono Pharmaceutical Co., Ltd.
 
Phase 3 / NDA
 
Selumetinib
 
MEK inhibitor for cancer
 
AstraZeneca, PLC
 
Phase 3
 
ASC08/Danoprevir
 
Protease inhibitor for Hepatitis C virus
 
Roche Holding AG
 
Phase 3 / NDA
 
Ipatasertib/GDC-0068
 
AKT inhibitor for cancer
 
Genentech, Inc.
 
Phase 3
 
Larotrectinib/LOXO-101
 
PanTrk inhibitor for cancer
 
Loxo Oncology, Inc.
 
Phase 2 / Registration Trial
 
Tucatinib/ONT-380
 
HER2 inhibitor for breast cancer
 
Cascadian Therapeutics, Inc.
 
Phase 2 / Registration Trial
 
Varlitinib/ASLAN001
 
Pan-HER2 inhibitor for gastric or breast cancer
 
ASLAN Pharmaceuticals Pte Ltd.
 
Phase 2 / Registration Trial
 
ARRY-797
 
p38 inhibitor for Lamin A/C-related dilated cardiomyopathy
 
 
 
Phase 2
 
Motolimod/VTX-2337
 
Toll-like receptor for cancer
 
Celgene Corp. / VentiRx Pharmaceuticals, Inc.
 
Phase 2
 
Prexasertib/LY2606368
 
CHK-1 inhibitor for cancer
 
Eli Lilly and Company
 
Phase 2
 
ARRY-382
 
CSF1R inhibitor for cancer
 
 
 
Phase 1 / 2
 
GDC-0575
 
CHK-1 inhibitor for cancer
 
Genentech, Inc.
 
Phase 1b
 
LOXO-292
 
RET inhibitor for cancer
 
Loxo Oncology, Inc.
 
Phase 1
 
LOXO-195
 
NTRK inhibitor for cancer
 
Loxo Oncology, Inc.

 
Phase 1

Binimetinib and Encorafenib
In March 2015, we regained development and commercialization rights to binimetinib, a MEK inhibitor, under the Termination and Asset Transfer Agreement with Novartis Pharma AG and Novartis Pharmaceutical Ltd. and to encorafenib, a BRAF inhibitor, under the Asset Transfer Agreement with Novartis Pharma AG (which we collectively refer to as the “Novartis Agreements”). Along with global ownership of both assets, Array received an upfront payment of $85.0 million from Novartis. We believe these programs present significant opportunity to Array in the area of oncology.


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